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Combine chili powder, cumin, salt and oregano in large plastic food storage bag. Add Cheddar and Monterey Jack cheese. Shake to coat cheese.
Heat 1/2 tablespoon Crisco Oil in medium skillet. Place one tortilla in pan and top with ? cup cheese mixture; top with a second tortilla. Cook 30 seconds, turn; cook 30 seconds longer. Repeat with additional Crisco Oil, remaining tortillas and cheese mixture. Cut each quesadilla into 8 wedges. Serve with salsa and sour cream.